Delysid (LSD 25) D-lysergic acid diethylamide tartrate Sugar-coated tablets containing 0.025 mg. (25 µg.). Ampoules of 1 ml. containing 0.1 mg. (100 µg.) for oral administration. The solution may also be injected s.c. or i.v. The effect is identical with that of oral administration but sets in more rapidly. PROPERTIES The administration of very small doses of Delysid (½-2 µg./kg. body weight) results in transitory disturbances of affect, hallucinations, depersonalization, reliving of repressed memories, and mild neuro-vegetative symptoms. The effect sets in after 30 to 90 minutes and generally lasts 5 to 12 hours. However, intermittent disturbances of affect may occasionally persist for several days. METHOD OF ADMINISTRATION For oral administration the contents of 1 ampoule of Delysid are diluted with distilled water, a 1% solution of tartaric acid or halogen-free tap water. The absorption of the solution is somewhat more rapid and more constant that that of the tablets. Ampoules which have not been opened, which have been protected against light and stored in a cool place are stable for an unlimited period. Ampoules which have been opened or diluted solutions retain their effectiveness for 1 to 2 days, if stored in a refrigerator. INDICATIONS AND DOSAGE a) Analytical psychotherapy, to elicit release of repressed material and provide mental relaxation, particularly in anxiety states and obsessional neuroses. The initial dose is 25 µg. (¼ of an ampoule or 1 tablet). This dose is increased at each treatment by 25 µg. until the optimum dose (usually between 50 and 200 µg.) is found. The individual treatments are best given at intervals of one week. b) Experimental studies on the nature of psychoses: By taking Delysid himself, the psychiatrist is able to gain an insight in the world of ideas and sensations of mental patients. Delysid can also be used to induced model psychoses of short duration in normal subjects, this facilitating studies on the pathogenesis of mental disease. In normal subjects, doses of 25 to 75 µg. are generally sufficient to produce a hallucinatory psychosis (on an average 1 µg./kg. body weight). In certain forms of psychosis and in chronic alcoholism, higher doses are necessary (2 to 4 µg./kg. body weight). PRECAUTIONS Pathological mental conditions may be intensified by Delysid. Particular caution is necessary in subjects with a suicidal tendency and in those cases where a psychotic development appears imminent. The psycho-affective lability and the tendency to commit impulsive acts may occasionally last for some days. Delysid should only be administered under strict medical supervision. The supervision should not be discontinued until the effects of the drug have completely worn off. ANTIDOTE The mental effects of Delysid can be rapidly reversed by the i.m. administration of 50 mg. chlorpromazine. Literature available on request. SANDOZ LTD., BASLE, SWITZERLAND 9792*-Z1540 e.-sp./d.-fr. Printed in Switzerland. From the product monograph.